I'm not on anything right now it is still stage 0 but yes I get woke up in the middle of the night with cramps in my calfs

I have CLL/SLL and I have constant pain in both upper arms and lower back, I get calf cramps in my sleep every night. I'm on Imbruvica, the nodes have gone down but the tiredness is never ending.

Yes mine always come in the middle of the night

I haven’t had any in my calves, but bad ones in my inner thigh, usually a night.