I had CAR-T after a 6 1/2 year "complete" remission from R-CHOP. CAR-T worked for about 6 weeks and then failed though we didn't know it had failed for about 2 months after the failure, after which the cancer came back with a vengeance and had me at death's door. We then immediately started treatment with the bispecific glofitumab ("Columvi"), after discovering the failure, where my LDH blood test immediately showed a very strong positive affect, and was then declared to be in complete remission(!) in my first "in treatment" PET scan, about 2 1/2 months after starting the glofitumab; this was the best and greatest surprise I've ever experienced in my life. I have now been in complete remission for 1 1/2 years and feel great. At the start of glofitumab my LDH stood at 1400 (very bad) and is now 162 smack in the middle of normal! A great advantage of glofitumab is that it is "off the shelf" so were able to start it immediately, rather than the 2+ months it took to do all the prep work for CAR-T. The fact that my LDH mirrored the ebb and flow of my cancer is not necessarily typical, according to my oncologist, which is why we were late in diagnosing the CAR-T failure. To me, glofitumab was a miracle! I should also mention that glofitumab had received expedited FDA approval less than three months before we discovered the CAR-T failure. I'm not at all saying that CAR-T is bad or usually fails, but in my case it did. My oncologist's experience with CAR-T has been quite good, but nowhere near perfect; no cancer treatment is perfect. I just hope the "powers that be" (I'm being polite here) allow cancer research to continue.

Hello! I have received the Car T Cell transplantation end of April and am now under supervision. My LDH was on the limit last time we checked (250) but I am fine for now. I received it because the R Pola CHP chemo failed and relapse came shortly before the end of Rituximab therapy. Have you been through this treatment as well?

I appreciate you sharing your experience. I want to be as aware as I can be of any potential outcomes and occurrences. To be aware is to be better prepared. I know to be active in my care and monitoring after my treatment.
Thank you.