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A MyLymphomaTeam Member asked a question 💭
Dallas, TX
July 27, 2025
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Primary Central Nervous System (PCNS) Lymphoma is a rare type of lymphoma that starts in the brain or spinal cord. It makes up less than 2% of lymphoma cases and most commonly appears as diffuse large B-cell lymphoma, though some cases can be T-cell lymphomas.

Risk factors include
- Having the Epstein-Barr virus
- Show Full Answer

Primary Central Nervous System (PCNS) Lymphoma is a rare type of lymphoma that starts in the brain or spinal cord. It makes up less than 2% of lymphoma cases and most commonly appears as diffuse large B-cell lymphoma, though some cases can be T-cell lymphomas.

Risk factors include:
- Having the Epstein-Barr virus
- Weakened immune system
- Autoimmune conditions
- Taking immunosuppressive medications
- Advanced age Common symptoms include:
- Headaches and nausea
- Memory loss
- Difficulty concentrating
- Behavioral and emotional changes
- Seizures in later stages

Treatment typically involves:
- High-dose chemotherapy (often starting with methotrexate)
- Whole brain radiation therapy
- Possible stem cell transplantation

Without treatment, prognosis is typically a few months. Regular follow-up with a healthcare team is essential as multiple body systems may be affected, requiring different specialists.

July 27, 2025

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