I would definitely wear a mask to fly & I am not a fan of masks in general - only for airplane.

absolutely wear a mask do not take any chances since your immune system is compromised

Wear a mask. Better safe than sorry. The sickest I ever got was from breathing contaminated air while flying.

Our immune systems are compromised My wife makes me be super cautious and I really have no problem with that

I absolutely would. All the folks that I know that have gotten COVID more recently had been traveling (either by air or on a cruise). I have so far turned down air travel because I just don't think the risk is worth it for me. You have to decide your own priorities. If you decide to go, masking, hand washing and etc are still a very good idea. Hope everything works out for you.