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How effective are targeted therapies for marginal zone lymphoma (MZL)?

Immunotherapy treatments like rituximab have shown promising effectiveness for MZL. Rituximab works by targeting specific proteins on B-cells to help destroy cancer cells. It can be used either as a standalone treatment or combined with chemotherapy for Show Full Answer

How effective are targeted therapies for marginal zone lymphoma (MZL)?

Immunotherapy treatments like rituximab have shown promising effectiveness for MZL. Rituximab works by targeting specific proteins on B-cells to help destroy cancer cells. It can be used either as a standalone treatment or combined with chemotherapy for potentially better results. The effectiveness varies by MZL subtype. MALT lymphoma, the most common form, typically responds well to treatment with a high 90% five-year survival rate. SMZL and NMZL have lower but still encouraging survival rates of 50-70%. Newer treatment options, including BTK inhibitors, are helping to improve outcomes for resistant or relapsed cases.

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