The main molecular subtypes of DLBCL are:
- Germinal Center B-Cell-Like (GCB) DLBCL - This is the most common subtype and typically responds better to treatment with better overall survival rates
- Activated B-Cell-Like (ABC) DLBCL - This subtype tends to be less responsive to treatment
- Type 3 DLBCL - Also called Show Full Answer
The main molecular subtypes of DLBCL are:
- Germinal Center B-Cell-Like (GCB) DLBCL - This is the most common subtype and typically responds better to treatment with better overall survival rates
- Activated B-Cell-Like (ABC) DLBCL - This subtype tends to be less responsive to treatment
- Type 3 DLBCL - Also called unclassifiable, this doesn't have characteristics of either GCB or ABC subtypes DLBCL can also be classified by location in the body:
- Primary Mediastinal Large B-Cell Lymphoma - Forms between the lungs
- Primary Central Nervous System Lymphoma - Develops in the brain or spinal cord
- Extranodal DLBCL - Can develop outside lymph nodes in organs like the intestines, stomach, kidneys, liver, bone marrow, or skin
Some people have DLBCL-NOS (not otherwise specified), meaning their cancer doesn't have any notable distinguishing characteristics.
May 9, 2025