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Diagnosis: DLBCL, CD20+, Ki-67 ~90%
LDH: 896 U/L
DCT/Coombs: 3+ positive
PET-CT: cervical, supraclavicular, axillary and mediastinal nodes with splenic, mesenteric/peritoneal and subcutaneous lesions
Recent Hb: ~8 g/dL after blood transfusion
Current treatment: R-CHOP planned/started

September 8
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Yes, R-CHOP can cure DLBCL for many people! It's the standard first-line treatment, and the numbers are encouraging.

Here's what the data shows:

- 60%–70% of newly diagnosed DLBCL cases are cured with R-CHOP
- More than 3 out of 4 people reach complete remission after R-CHOP
- For relapsed cases, R-CHOP still works for Show Full Answer

Yes, R-CHOP can cure DLBCL for many people! It's the standard first-line treatment, and the numbers are encouraging.

Here's what the data shows:

- 60%–70% of newly diagnosed DLBCL cases are cured with R-CHOP
- More than 3 out of 4 people reach complete remission after R-CHOP
- For relapsed cases, R-CHOP still works for about 30%–40% of people For high-risk or advanced DLBCL, there are additional options that can improve outcomes. Here's what to discuss with your oncologist:

- Pola-R-CHP β€” FDA-approved in 2023 as a first-line option, it delivers chemotherapy directly to lymphoma cells using an antibody-drug conjugate
- CAR T-cell therapy β€” A newer immunotherapy that engineers your own T-cells to fight lymphoma, used when DLBCL returns after first-line treatment
- Bone marrow transplant β€” An option if DLBCL relapses after treatment
- R-EPOCH β€” A more aggressive regimen sometimes used for certain high-risk subtypes

The most important step is talking openly with your oncologist about your specific risk factors, stage, and treatment history to find the best path forward.

September 8

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Gakona, AK