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What is triple-hit lymphoma (THL)?

Triple-hit lymphoma is an aggressive form of non-Hodgkin lymphoma that affects B cells (white blood cells) in the immune system. It's considered very rare, making up about 2% of B-cell lymphomas and tends to occur more frequently in elderly adults, particularly males. THL is caused by Show Full Answer

What is triple-hit lymphoma (THL)?

Triple-hit lymphoma is an aggressive form of non-Hodgkin lymphoma that affects B cells (white blood cells) in the immune system. It's considered very rare, making up about 2% of B-cell lymphomas and tends to occur more frequently in elderly adults, particularly males. THL is caused by genetic mutations called translocations that affect three specific genes: MYC, BCL2, and BCL6. These genes normally control cell division and death, but when mutated, they cause excessive cell division and reduced cell death, leading to cancer development.

Common symptoms can include fevers, night sweats, and sudden weight loss, which are known as B symptoms. These symptoms are characteristic of various forms of lymphoma.

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Triple-Hit Lymphoma: Your Guide