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Double-hit lymphoma (DHL) is an aggressive form of non-Hodgkin lymphoma that develops from B cells (white blood cells). It's considered a rare subtype, affecting about 5% of people with diffuse large B-cell lymphoma (DLBCL). DHL tends to occur more frequently in older adults and slightly more often in males. DHL is caused Show Full Answer

Double-hit lymphoma (DHL) is an aggressive form of non-Hodgkin lymphoma that develops from B cells (white blood cells). It's considered a rare subtype, affecting about 5% of people with diffuse large B-cell lymphoma (DLBCL). DHL tends to occur more frequently in older adults and slightly more often in males. DHL is caused by genetic mutations called translocations, where pieces of chromosomes break off and recombine abnormally. The most common form involves mutations in two genes: MYC and BCL2. When a third gene (BCL6) is involved, it's called triple-hit lymphoma. These genetic changes can make the cancer more difficult to treat.

Common symptoms include:
- Swollen lymph nodes
- Fatigue
- Breathing difficulties
- Loss of appetite

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What Is Double-Hit Lymphoma? Symptoms, Survival Rate, and More