What is high-grade B-cell non-Hodgkin lymphoma?
High-grade B-cell lymphomas are aggressive, fast-growing types of non-Hodgkin lymphoma that develop from B cells, the white blood cells that make antibodies to fight infection. These lymphomas can progress quickly and often require timely treatment.
B-cell lymphomas account Show Full Answer
What is high-grade B-cell non-Hodgkin lymphoma?
High-grade B-cell lymphomas are aggressive, fast-growing types of non-Hodgkin lymphoma that develop from B cells, the white blood cells that make antibodies to fight infection. These lymphomas can progress quickly and often require timely treatment.
B-cell lymphomas account for about 85 percent to 90 percent of all non-Hodgkin lymphomas. The aggressive types grow rapidly but are often highly treatable, with many people achieving complete remission after treatment. Common types of aggressive B-cell lymphomas include:
- Diffuse large B-cell lymphoma (DLBCL) - the most common form, accounting for about one-third of all NHL cases
- Burkitt lymphoma
- Lymphoblastic lymphoma
- Mantle cell lymphoma
DLBCL most often affects older adults but can occur at any age. Early symptoms typically include rapidly swelling lymph nodes in the neck, armpits, and groin, often combined with B symptoms like fever, night sweats, and weight loss. Although these are aggressive cancers, they generally respond well to intensive treatment. Most people with high-grade B-cell lymphoma are treated with chemotherapy regimens combined with targeted antibody drugs like rituximab. Radiation therapy may also be used in some cases.
Despite being fast-growing, many people achieve complete remission, meaning there's no evidence of cancer after treatment.
April 5
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