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Real members of MyLymphomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Are there any new theories in IgM and Waldenstrim since the paper in 2917?

A MyLymphomaTeam Member asked a question 💭
June 23, 2025
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A MyLymphomaTeam Member

I have been diagnosed with IgM MGUS and in watch and wait, I haven’t had a bone marrow biopsy nore have I seen any specialists. I haven’t several swollen lymph nodes. I sleep a lot I itch. I have peripheral neuropathy. I drool a lot and sometimes my nose is runny. I have swollen feet . I’m in my eighties.

June 23, 2025
MyLymphomaTeam

Recent research has shown that Waldenstrom's macroglobulinemia (WM) involves abnormal B-cells producing excessive amounts of IgM proteins. These proteins accumulate in the blood, causing it to thicken and slow circulation, which can lead to various complications.

A significant finding is that mutations in the MYD88 gene may Show Full Answer

Recent research has shown that Waldenstrom's macroglobulinemia (WM) involves abnormal B-cells producing excessive amounts of IgM proteins. These proteins accumulate in the blood, causing it to thicken and slow circulation, which can lead to various complications.

A significant finding is that mutations in the MYD88 gene may contribute to the development of WM. This genetic component helps explain why the condition develops and could potentially lead to more targeted treatments. The impact of IgM levels has become better understood - higher IgM levels are now associated with poorer outcomes. This has led to the development of the International Prognostic Scoring System for Waldenstrom Macroglobulinemia (ISSWM), which helps healthcare teams better predict disease progression and plan appropriate treatments.

June 23, 2025

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