It sounds like you're going through a really tough time right now, and that's completely understandable. When treatments stop working, it can feel overwhelming — but there are still options worth exploring with your care team.
Waldenstrom's macroglobulinemia (WM) is a slow-growing form of non-Hodgkin lymphoma. Even when Show Full Answer
It sounds like you're going through a really tough time right now, and that's completely understandable. When treatments stop working, it can feel overwhelming — but there are still options worth exploring with your care team.
Waldenstrom's macroglobulinemia (WM) is a slow-growing form of non-Hodgkin lymphoma. Even when earlier treatments stop working, there are several other approaches that may be considered, including:
- Targeted therapy drugs like Brukinsa (zanubrutinib) or Imbruvica (ibrutinib)
- Immunotherapy such as Rituxan (rituximab), often combined with other treatments
- Stem cell transplantation — using either your own cells or a donor's
- Plasmapheresis to manage thick blood caused by high IgM levels
- Clinical trials exploring newer treatment combinations
- CAR-T cell therapy, a newer approach being studied for lymphoma
The most important next step is having an open conversation with your oncologist about what options remain, including clinical trials specifically for WM.
A great resource to explore is the Lymphoma Research Foundation at lymphoma.org, which has detailed WM-specific information.
Please don't lose hope — new treatments continue to emerge, and your care team can help map out the best path forward.
September 29
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