Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a slow-growing form of Hodgkin lymphoma that typically affects people between 30-50 years old and is more common in men. While rare (only about 5% of all Hodgkin lymphoma cases), NLPHL generally has a positive outlook.
The most common and often only symptom is Show Full Answer
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a slow-growing form of Hodgkin lymphoma that typically affects people between 30-50 years old and is more common in men. While rare (only about 5% of all Hodgkin lymphoma cases), NLPHL generally has a positive outlook.
The most common and often only symptom is painless, enlarged lymph nodes, typically in the neck, armpit, or groin areas. Unlike other forms of lymphoma, people with NLPHL usually don't experience B symptoms (fever, night sweats, weight loss). Here's some encouraging news about NLPHL:
• It's usually diagnosed in early stages (3 out of 4 cases)
• Treatment options can be less aggressive than other lymphomas
• Some early-stage cases may use a watch-and-wait approach
• The survival rates are very good
• Treatment plans are personalized based on your stage and symptoms
While NLPHL is curable, it's important to maintain regular follow-up care as relapses can occur years after remission.
September 4, 2025
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