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I had an unknown virus at the age of 18 while living in Brazil. I am now 81 and have large B cell nhl of the bone. Could this be related

A MyLymphomaTeam Member asked a question 💭
Port Charlotte, FL

I also had breast cancer 30 years apart in 1989 right breast and 2009 left breast. I have had chemo in 89 and many radiation treatments approximately 160. I am currently taking Rituxan every 8 weeks since diagnosis in 2023. I have a few other conditions such as afib, bp issues, cholesterol issues. I do not carry the cancer gene. My parents were both healthy. My dad’s side everyone lived to 100s. I feel great other than RA. Why am I still kicking

January 2
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Viral Infections and the Risk for Lymphoma Read Article...
MyLymphomaTeam

Could an unknown virus from your youth be related to your diffuse large B-cell lymphoma (DLBCL)?

It's possible, though difficult to confirm after so many years. Certain viruses are linked to lymphoma development, including Epstein-Barr virus, hepatitis B and C, and HIV. These viruses can create genetic mutations in immune Show Full Answer

Could an unknown virus from your youth be related to your diffuse large B-cell lymphoma (DLBCL)?

It's possible, though difficult to confirm after so many years. Certain viruses are linked to lymphoma development, including Epstein-Barr virus, hepatitis B and C, and HIV. These viruses can create genetic mutations in immune cells that may contribute to lymphoma years later.

However, your history of previous cancer treatments is likely more relevant. Both chemotherapy from 1989 and your extensive radiation treatments (approximately 160) are known risk factors for developing DLBCL later in life. Radiation exposure from treating other cancers is specifically connected to NHL subtypes, including DLBCL.

Your rheumatoid arthritis also plays a role. Autoimmune conditions like RA are associated with increased lymphoma risk, particularly DLBCL. The chronic inflammation from RA can create an environment that may help abnormal cells develop. As for why you're "still kicking" at 81 and feeling great despite everything - that's wonderful! Your strong family genetics (with relatives living to 100), early detection and treatment of your lymphoma with Rituxan, and your overall positive outlook are all working in your favor. Many people with DLBCL respond well to treatment, especially when caught early.

Keep working with your care team to manage your various conditions, and celebrate your resilience!

January 2

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