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What tissue preparation steps happen before immunohistochemistry (IHC) staining?

Before IHC staining can be performed, tissue samples must first be collected through a biopsy procedure. The type of biopsy depends on where the lymphoma is located:

- Excisional or incisional biopsy: Removes an entire lymph node or a large Show Full Answer

What tissue preparation steps happen before immunohistochemistry (IHC) staining?

Before IHC staining can be performed, tissue samples must first be collected through a biopsy procedure. The type of biopsy depends on where the lymphoma is located:

- Excisional or incisional biopsy: Removes an entire lymph node or a large portion of it
- Core needle biopsy: Uses a needle to collect a tissue sample from harder-to-reach areas
- Punch biopsy: Removes a section of skin and deeper tissue layers (for certain lymphoma types)
- Bone marrow biopsy: Collects bone marrow tissue samples

Once the tissue sample is obtained, a pathologist examines it under a microscope to look for cancer cells and their characteristics. The tissue is then prepared for IHC testing.

IHC works by manipulating specific proteins in the tissue sample to make them visible under a microscope. This technique helps identify lymphoma cells by recognizing specific protein markers on the cell surface, which is crucial for confirming the type of lymphoma and planning treatment.

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