MyLymphomaTeam

Are you looking for others with lymphoplasmacytic lymphoma (LPL) without Waldenström macroglobulinemia (WM)?

LPL can occur without the high IgM levels that define WM. Your situation with elevated kappa light chains and peripheral neuropathy as the main symptom is a recognized presentation of LPL.

Your treatment plan of Show Full Answer

Are you looking for others with lymphoplasmacytic lymphoma (LPL) without Waldenström macroglobulinemia (WM)?

LPL can occur without the high IgM levels that define WM. Your situation with elevated kappa light chains and peripheral neuropathy as the main symptom is a recognized presentation of LPL.

Your treatment plan of Rituximab-Bendamustine is a standard approach for LPL. Bendamustine is a chemotherapy drug commonly used for this type of lymphoma, and Rituximab is a targeted therapy that helps the immune system fight cancer cells.

Regarding your peripheral neuropathy symptoms - the lower leg weakness and paresthesia (tingling/numbness) - these can indeed be related to elevated light chains. Peripheral neuropathy causes symptoms like:

- Tingling sensations, often starting in hands and feet
- Muscle weakness
- Feeling uncoordinated or having trouble moving limbs
- Pain or unusual sensations

The goal of reducing your free light chains from 400 to normal levels (10-20) is reasonable, and there's hope that lowering these levels may improve your neuropathy symptoms. However, it's important to know that neuropathy improvement can take time, and results vary from person to person.

Make sure to discuss any changes in your symptoms with your cancer care team during treatment.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Waldenstrom’s Macroglobulinemia: An Overview

Waldenstrom’s Macroglobulinemia: Treatment Options