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I have SLL with enlarged lymph nodes, Stage III. My blood lymphocytes are normal as are all my blood tests. Can you help me understand how it is I have a blood cancer rather than cancer of the lymphatic system? Thanks!

March 5
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A MyLymphomaTeam Member

If it’s confined to your skin? How can you have blood cancer? or cancer in your lymphatic system when the cancer is only in your skin? How does that make sense?

March 5
A MyLymphomaTeam Member

How can you have blood cancer when you have Primary Cutaneous Marginal Zone B-Cell extra nodal Non-Hodgkin’s lymphoma?

March 5
MyLymphomaTeam

How can you have a blood cancer when your blood tests are normal?

Great question! The confusion makes sense, but here's what's happening: SLL and CLL are actually the same disease, just showing up in different places in your body.

When the cancerous B cells are mainly in your lymph nodes (like in your case), it's called Show Full Answer

How can you have a blood cancer when your blood tests are normal?

Great question! The confusion makes sense, but here's what's happening: SLL and CLL are actually the same disease, just showing up in different places in your body.

When the cancerous B cells are mainly in your lymph nodes (like in your case), it's called Small Lymphocytic Lymphoma (SLL). When those same cancer cells are primarily in your blood and bone marrow, it's called Chronic Lymphocytic Leukemia (CLL).

Since your cancer cells are concentrated in your lymph nodes rather than circulating in your blood, your blood tests look normal. That's why you have SLL instead of CLL.

The term "blood cancer" can be confusing because it's used as an umbrella term for cancers affecting blood cells, even when those cells aren't actually in the bloodstream. In your case, the cancer involves B cells (a type of white blood cell), but they're gathering in your lymph nodes rather than your blood.

Think of it this way: it's the same type of cancer cell, just in a different location. Your Stage III diagnosis reflects that the lymph nodes on both sides of your diaphragm are involved, which is why it's classified as advanced stage.

March 5

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