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Has any body ages in the 70's undergo an Allogeneic bone marrow transplant?

A MyLymphomaTeam Member asked a question 💭
Oceanside, NY

I am 77 years old with Mantle Cell Lymphoma. I was diagnosed in in 2023. It is aggressive as I went through 3 procedures including Car t that failed. Currently I am on Glofitamab that brought me to remission on the pet scan. A new test called clonoSEQ or MRD showed I still had a little lymphoma left hidden I guess. Because I am in decent shape they suggested an Allogeneic bone marrow transplant. I dont like all the side effects but am open to any information or experience.

March 23
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Reactions
A MyLymphomaTeam Member

Bruce I hated the thought of an extended stay in the hospital with the cart t and the chances it would be successful gave me a low level of comfort of having it done.
I am happy with my decision for now and being able to enjoy my golf hobby

March 27
A MyLymphomaTeam Member

Thanks for the answer Bill. As I said I accepted car t and after a month or so in the hospital it eventually failed. I believe I am going to decline the allogeneic cell transplant and like you exercise and continue on. I was on bruzinca for two years as my first medication. Good stuff. Take care and stay well.

March 24
A MyLymphomaTeam Member

Bruce, I am 78 with MCL diagnosed in Sept 2023. I was offered Cart t but after reading all of the side effects I declined. I am on a stretching program every day and golf 2 to 3 times a week . Other than fatigue and needing daily naps I am happy with my progress. My suggestion is try to stay active. I am just going to stay the course with Rituxan and Brukinsa

March 24
MyLymphomaTeam

Has anyone in their 70s undergone an allogeneic bone marrow transplant for mantle cell lymphoma?

It's understandable to have concerns about an allogeneic stem cell transplant at 77, especially given the potential side effects. While the procedure is more commonly recommended for younger patients, being in decent physical Show Full Answer

Has anyone in their 70s undergone an allogeneic bone marrow transplant for mantle cell lymphoma?

It's understandable to have concerns about an allogeneic stem cell transplant at 77, especially given the potential side effects. While the procedure is more commonly recommended for younger patients, being in decent physical shape is an important factor that doctors consider when determining eligibility.

Age does play a role in outcomes. Research shows that people under 50 with mantle cell lymphoma have better survival rates than those over 75. However, your overall health status and how well you've tolerated previous treatments matter significantly in the decision-making process.

The main side effects to be aware of include:
- Nausea and vomiting
- Mouth sores
- Increased infection risk
- Lung inflammation
- Graft-versus-host disease (where donated cells may attack your body's tissues)

Since you've already been through CAR T-cell therapy and are now responding to Glofitamab with minimal residual disease, your medical team likely sees the transplant as a way to achieve deeper, longer-lasting remission.

It would be helpful to have a detailed conversation with your transplant team about:
- Their experience with patients in your age group
- Expected recovery timeline
- Quality of life considerations
- Alternative treatment options if you decide against transplant

Your situation is complex, and connecting with others who've faced similar decisions could provide valuable perspective.

March 23

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