When B-cell non-Hodgkin lymphoma (NHL) spreads to the bone or bone marrow, doctors use a combination of tests to confirm this. Here's what's typically involved:
Bone Marrow Biopsy & Aspiration
These two tests are often done together and are the most direct way to check for lymphoma cells in the bone marrow
- A biopsy uses Show Full Answer
When B-cell non-Hodgkin lymphoma (NHL) spreads to the bone or bone marrow, doctors use a combination of tests to confirm this. Here's what's typically involved:
Bone Marrow Biopsy & Aspiration
These two tests are often done together and are the most direct way to check for lymphoma cells in the bone marrow:
- A biopsy uses a larger needle to remove a small piece of solid bone marrow tissue
- An aspiration uses a smaller needle to remove liquid bone marrow
- Samples are usually taken from the hip bone under local anesthetic
Imaging Tests
Imaging helps locate where lymphoma may have spread:
- PET scans are especially useful — they can detect small numbers of cancer cells even in areas that look normal on other scans
- CT scans create detailed 3D images to check for affected areas
- MRI can also be used to look for internal signs of spread
Blood Tests
A complete blood count (CBC) can give clues, such as low red blood cell or platelet counts, which may suggest bone marrow involvement. Doctors may also check levels of proteins like LDH and beta-2 microglobulin as markers of cancer activity. It's worth noting that bone marrow tests are more commonly recommended for aggressive or advanced-stage B-cell NHL. Always speak with your oncologist about which tests are right for your specific situation, as the approach can vary depending on your subtype and symptoms.
23 hours ago
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