MyLymphomaTeam

Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma that develops from immune system cells called B lymphocytes. This rare cancer primarily forms in the mediastinum, which is the space between the lungs. It accounts for only 2-4% of all non-Hodgkin lymphomas and most commonly affects young Show Full Answer

Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma that develops from immune system cells called B lymphocytes. This rare cancer primarily forms in the mediastinum, which is the space between the lungs. It accounts for only 2-4% of all non-Hodgkin lymphomas and most commonly affects young adults, particularly women, though it can also occur in children. Most people with PMBCL develop a large tumor (greater than 10 centimeters) in the early stages of the disease. Common symptoms include difficulty swallowing, rapid breathing, coughing, and blood clots in the veins. Many patients also experience vena cava syndrome, which can cause breathing difficulties, facial and abdominal swelling, and visible large veins in the chest. Diagnosis typically involves lymph node biopsy, where tissue is removed either through surgery or needle biopsy to examine for cancer cells. Doctors may also perform bone marrow testing to determine if the disease has spread. When viewed under a microscope, PMBCL cancer cells share characteristics with both classical Hodgkin lymphoma and diffuse large B-cell lymphoma (DLBCL).

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Primary Mediastinal B-Cell Lymphoma — An Overview