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Real members of MyLymphomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I was diagnosed with DLBCL at 56 years of age in August 2024. I failed the first line treatment, R-CHOP. After that, I participated in a salvage chemotherapy clinical trial with epicortimab, cisplatin, dexamethasone, and gemcitabine. I achieved unreliable remission from the salvage chemotherapy. Although the PET scan was clear, my oncologist said that I probably still had microscopic levels of DLBCL. So, she had me do autologous CAR-T. However, it did not work... I had a PET scan one month after… read more

July 14, 2025
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MyLymphomaTeam

Yes, people can achieve remission even after multiple treatment attempts. While the success rates for second-line treatments are lower than first-line treatments, studies show that about 44% of patients who relapse after R-CHOP can achieve a second remission with additional treatments. Your treatment plan aligns with Show Full Answer

Yes, people can achieve remission even after multiple treatment attempts. While the success rates for second-line treatments are lower than first-line treatments, studies show that about 44% of patients who relapse after R-CHOP can achieve a second remission with additional treatments. Your treatment plan aligns with current medical approaches. For patients who aren't eligible for bone marrow transplant or who have had unsuccessful treatments, options include Polatuzumab vedotin-piiq (Polivy) with bendamustine and rituximab (POLA-BR), which you're starting. Clinical trials, like the allogeneic CAR T-cell therapy you're considering, represent some of the newest advancements in treating resistant DLBCL.

July 14, 2025

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