Is there a connection between non-Hodgkin lymphoma (NHL) and Sjögren's disease?
Yes, there is a connection. People diagnosed with Sjögren's disease have a significantly higher risk of developing NHL compared to the general population. However, it's important to know that the actual chances of developing lymphoma remain Show Full Answer
Is there a connection between non-Hodgkin lymphoma (NHL) and Sjögren's disease?
Yes, there is a connection. People diagnosed with Sjögren's disease have a significantly higher risk of developing NHL compared to the general population. However, it's important to know that the actual chances of developing lymphoma remain very small, even with this increased risk.
The connection appears to work both ways. There's some research suggesting that having NHL might also increase the risk of developing Sjögren's disease, though more studies are needed to confirm this relationship.
Why This Connection Exists
The link between these conditions centers around B lymphocytes (B cells), which are white blood cells that produce antibodies as part of your immune system.
In Sjögren's disease, B cells become overactive and build up in salivary glands and other areas, causing inflammation. Since NHL most often starts in B lymphocytes, the constant overstimulation of these cells may lead to the abnormalities that cause B-cell lymphoma.
Risk Factors to Watch For
Certain signs may indicate a higher risk of developing lymphoma if you have Sjögren's:
- Persistent enlargement of salivary glands
- Swollen lymph nodes
- Cryoglobulinemic vasculitis (blood vessel inflammation)
If you notice any of these symptoms, contact your doctor right away.
December 3, 2025
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