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What's the difference between marginal zone NHL and primary cutaneous marginal zone lymphoma?

Marginal zone lymphoma (MZL) is a type of non-Hodgkin lymphoma that includes three main subtypes based on location:

- Extranodal MZL (MALT lymphoma): Develops outside lymph nodes in tissues like the stomach, lungs, skin, and Show Full Answer

What's the difference between marginal zone NHL and primary cutaneous marginal zone lymphoma?

Marginal zone lymphoma (MZL) is a type of non-Hodgkin lymphoma that includes three main subtypes based on location:

- Extranodal MZL (MALT lymphoma): Develops outside lymph nodes in tissues like the stomach, lungs, skin, and digestive system
- Nodal MZL: Occurs in the lymph nodes
- Splenic MZL: Affects the spleen and blood

Primary cutaneous marginal zone lymphoma is a specific form of extranodal MZL that develops in the skin. It's part of the broader MALT lymphoma category, which makes up about 61% of all marginal zone lymphoma cases.

The key difference is location: while marginal zone NHL is the umbrella term for all three subtypes, primary cutaneous marginal zone lymphoma specifically refers to cases where the lymphoma starts in the skin tissue. Both are considered slow-growing (indolent) lymphomas.

MALT lymphomas can occur in various mucosa-lined areas including the mouth, digestive system, nose, and lungs - with skin being one of these extranodal sites.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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