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Real members of MyLymphomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Is muscle cramping in the arms, legs, chest and back a sign of returning lymphoma

A MyLymphomaTeam Member asked a question 💭
Palm Coast, FL
May 7
 · 
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A MyLymphomaTeam Member

Spot on reply. ALWAYS CONSULT YOUR ONCOLOGIST. What you get here are possible ideas from others going through the same thing or have gone through it. We offer opinions but DOCTORS COME FIRST. I pray you get your answer from your doctor. Just as a side note. prayers to God for his healing touch has always been first on my list and God will work his miracles through your oncologist. Sure worked for me. 5 plus years in remission from my AML

May 7
A MyLymphomaTeam Member

Hey JoyFargo,
Sorry I didn't get back to your message to me...

I was having chest pains and discomfort months ago which I thought was due to having gerd. The pains/discomfort wouldn't go away with my meds, so I went to the ER and that is how I found out I had Hodgkin's Lymphoma. I did 12 rounds of ABVD chemo and have been cancer free since March 2026.

As for your question I was told before that pains after having lymphoma can be side effects left over from chemo. It is always best though to contact your doctors and let them know your symptoms, so they can run tests.

I was having more chest pains a few weeks ago, so got scans done and I am okay! Just gerd again and side effects from chemo.

Hope you feel better soon!

May 7 (edited)
MyLymphomaTeam

Can muscle cramping in the arms, legs, chest, and back be a sign of lymphoma recurrence?

Muscle cramping and pain can be connected to lymphoma in a few ways. It's worth taking these symptoms seriously, especially if they're new or worsening.

Here are some possible lymphoma-related causes of pain in those areas:

- Show Full Answer

Can muscle cramping in the arms, legs, chest, and back be a sign of lymphoma recurrence?

Muscle cramping and pain can be connected to lymphoma in a few ways. It's worth taking these symptoms seriously, especially if they're new or worsening.

Here are some possible lymphoma-related causes of pain in those areas:

- Enlarged lymph nodes or tumors pressing on nearby nerves, tissues, or organs can cause pain in the chest, abdomen, and back
- Bone involvement — lymphoma can occasionally spread to bones, causing pain in the legs, spine, and other areas
- Nerve damage (peripheral neuropathy) from lymphoma or its treatments can cause pain, tingling, burning, or weakness
- Treatment side effects — medications like Neulasta or Udenyca (used to boost white blood cells) are known to cause significant bone and muscle pain A MyLymphomaTeam member shared: "I have joint pain most days of the week. It comes and goes." Others have reported long-lasting pain even years after treatment ended.

While these symptoms don't automatically mean recurrence, new or worsening muscle cramping across multiple areas of the body is absolutely worth reporting to your care team right away. They can evaluate whether it's related to lymphoma activity, treatment effects, or something else entirely.

Don't wait on this one — early reporting gives your team the best chance to act quickly if needed.

May 7

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