Yes, Waldenstrom's macroglobulinemia (WM) can transform into diffuse large B-cell lymphoma (DLBCL), though this is not common. This transformation is sometimes called "Richter's transformation" in related B-cell cancers and represents a shift from a slow-growing to a more aggressive lymphoma. When this happens, symptoms may Show Full Answer
Yes, Waldenstrom's macroglobulinemia (WM) can transform into diffuse large B-cell lymphoma (DLBCL), though this is not common. This transformation is sometimes called "Richter's transformation" in related B-cell cancers and represents a shift from a slow-growing to a more aggressive lymphoma. When this happens, symptoms may change or worsen more rapidly. Signs to watch for include:
- Rapidly enlarging lymph nodes
- Sudden worsening of fatigue
- Unexplained fever, night sweats, or weight loss
- New or worsening pain
It's really important to keep up with regular monitoring appointments so your care team can catch any changes early. If you notice any sudden changes in how you're feeling, reaching out to your doctor promptly is the best step to take.
September 1
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