How does splenic marginal zone lymphoma (SMZL) spread in the body?
SMZL is a slow-growing (indolent) lymphoma that primarily affects the spleen and bone marrow. It can spread, but it tends to do so gradually. Here's where SMZL can spread to:
- Spleen – the main site where abnormal B cells build up
- Bone marrow – commonly Show Full Answer
How does splenic marginal zone lymphoma (SMZL) spread in the body?
SMZL is a slow-growing (indolent) lymphoma that primarily affects the spleen and bone marrow. It can spread, but it tends to do so gradually. Here's where SMZL can spread to:
- Spleen – the main site where abnormal B cells build up
- Bone marrow – commonly involved alongside the spleen
- Blood – cancer cells can circulate in the bloodstream
- Lymph nodes – enlarged lymph nodes (lymphadenopathy) can be a sign of spread
When SMZL cells are found outside the spleen and bone marrow, this is associated with a poorer outlook. In some cases, SMZL can become more aggressive. About 3 in 10 people develop a faster-growing form, and it can sometimes transform into diffuse large B-cell lymphoma (DLBCL), which is a more aggressive type of lymphoma.
It's always worth discussing any concerns about spread or progression with your healthcare team, as they can give the most personalized guidance based on your specific situation.
September 5
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