MyLymphomaTeam

Triple-hit lymphoma (THL) diagnosis requires several specific medical tests. The key diagnostic procedures include:

A lymph node biopsy, which involves removing either part or all of a lymph node to examine the tissue for cancer cells under a microscope. This is a crucial first step in diagnosis.

Fluorescence in situ Show Full Answer

Triple-hit lymphoma (THL) diagnosis requires several specific medical tests. The key diagnostic procedures include:

A lymph node biopsy, which involves removing either part or all of a lymph node to examine the tissue for cancer cells under a microscope. This is a crucial first step in diagnosis.

Fluorescence in situ hybridization (FISH) testing is essential for confirming THL. This specialized test uses fluorescent molecules to identify the three specific gene rearrangements (MYC, BCL2, and BCL6) that characterize triple-hit lymphoma. Additional diagnostic tests typically include:

- Bone marrow biopsy and aspiration to check for cancer cells
- Blood tests to check for elevated levels of lactate dehydrogenase (LDH)
- Spinal tap (lumbar puncture) to check for central nervous system involvement

These tests help determine the extent of disease spread and guide treatment planning. Due to THL's aggressive nature, treatment typically begins as soon as possible after diagnosis with intensive chemotherapy combined with rituximab.

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Triple-Hit Lymphoma: Your Guide