What are the treatment options for Nodular Lymphocyte-Predominant Hodgkin Lymphoma?
Treatment for NLPHL depends on the stage of disease, symptoms, and overall health. Because NLPHL typically grows slowly and is often caught early, it may not always require immediate aggressive treatment.
Early-Stage NLPHL (Stage 1 or 2):
Show Full Answer
What are the treatment options for Nodular Lymphocyte-Predominant Hodgkin Lymphoma?
Treatment for NLPHL depends on the stage of disease, symptoms, and overall health. Because NLPHL typically grows slowly and is often caught early, it may not always require immediate aggressive treatment.
Early-Stage NLPHL (Stage 1 or 2):
For people with minimal symptoms, treatment options include:
* Watch and wait - Active surveillance where treatment is delayed until symptoms worsen
* Surgery - Removal of affected lymph nodes, especially if limited to one area
* Radiation therapy - Involved-site radiation therapy (ISRT) to target specific areas
When More Aggressive Treatment Is Needed:
People with B symptoms (fever, night sweats, weight loss), bulky disease, or advanced stages (3 and 4) may need:
* Chemotherapy regimens such as:
* ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)
* CHOP or R-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone, with or without rituximab)
* CVP (cyclophosphamide, vinblastine, prednisone)
* Targeted therapy - Rituximab targets the CD20 protein found on NLPHL cells and can be used alone or combined with chemotherapy and radiation
The prognosis for NLPHL is generally very good, with excellent chances for cure due to its slow growth and early detection.
January 6
Join
Your Privacy Choices
