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Real members of MyLymphomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Hi MLT Family, what is your experience with rituximab and chemo together?

A MyLymphomaTeam Member asked a question 💭
Rock Hill, SC
August 19, 2025
 · 
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A MyLymphomaTeam Member

NelleGrant,
Hi! I have had rchop chemo which includes rituxin for DLBCL. I had 6 treatments 1 every 3 weeks. I lost my hair (but it did come back after treatments were over) I feel that it was a cumulative effect. After the first chemo my lymphnodes got alot smaller. I had a rough time the first night after treatment. But as time went by, it got better. I had fatigue and nausea. Take the antinausea medication whether you need it or not on time. I was told to eat protein for my blood. I ate peanut butter on bagels when I was nauseated. I've been in remission for 4 1/2yrs. Good luck on your upcoming treatment. Kelly

August 20, 2025
MyLymphomaTeam

R-CHOP is a common treatment combining rituximab with chemotherapy drugs. This combination therapy typically involves:

• Rituximab (immunotherapy)
• Cyclophosphamide
• Doxorubicin
• Vincristine
• Prednisone (taken as a tablet)

Treatment usually consists of 6 cycles, given once every 21 days, though some may receive it Show Full Answer

R-CHOP is a common treatment combining rituximab with chemotherapy drugs. This combination therapy typically involves:

• Rituximab (immunotherapy)
• Cyclophosphamide
• Doxorubicin
• Vincristine
• Prednisone (taken as a tablet)

Treatment usually consists of 6 cycles, given once every 21 days, though some may receive it every 14 days. Each cycle includes 5 days of treatment followed by a rest period. The good news is that R-CHOP has shown to be effective, with potential to cure around 60% of DLBCL cases. While rituximab specifically targets cancer cells with fewer side effects, the chemotherapy portion may affect healthy cells too. Common side effects include decreased blood cell counts, which can affect your body's ability to fight infections.

Early-stage lymphoma may require fewer cycles, and your doctor might recommend additional radiation therapy depending on your specific situation.

August 19, 2025

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